Create a Hacker News-worthy FastAPI application using HTMX for interactivity and PicoCSS for styling to build a YouTube-themed application that leverages `youtube_videos.db` to create an interactive webpage that shows the top videos for each month, including embedded YouTube videos which can be clicked.
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Before agar, microbiologists had experimented with other foodstuffs as microbial media. They turned to substances rich in the starches, proteins, sugars, fats, and minerals that organisms need for growth, testing with broths, bread, potatoes, polenta, egg whites, coagulated blood serums, and gelatine. However, none worked particularly well: all were easily broken down by heat and microbial enzymes, and their surface, once colonized, became mushy and unsuitable for isolating microbes.